Academic Research
Ancestrally Diverse Cohorts are Crucial for Autism Genetics Studies
Gogate A. et al. (2024). The genetic landscape of autism spectrum disorder in an ancestrally diverse cohort. npj Genomic Medicine, 9, 62. DOI: 10.1038/s41525-024-00444-6
Inherited Risk is Polygenic and Additive
Klei, L., et al. (2012). Common genetic variants, acting additively, are a major source of risk for autism. Molecular autism, 3(1), 9. https://doi.org/10.1186/2040-2392-3-9
Discovery Starts with
the Right Data
Buxbaum JD, Bolshakova N, Brownfeld JM, Anney RJ, Bender P, Bernier R, Cook EH, Coon H, Cuccaro M, Freitag CM, Hallmayer J, Geschwind D, Klauck SM, Nurnberger JI, Oliveira G, Pinto D, Poustka F, Scherer SW, Shih A, Sutcliffe JS, Szatmari P, Vicente AM, Vieland V, Gallagher L. The Autism Simplex Collection: an international, expertly phenotyped autism sample for genetic and phenotypic analyses. Mol Autism. 2014 May 20;5:34. doi: 10.1186/2040-2392-5-34. PMID: 25392729; PMCID: PMC4228819.
Genome-Wide Linkage and
Association Scan Reveals
Novel Loci for Autism
Weiss LA, Arking DE; Gene Discovery Project of Johns Hopkins & the Autism Consortium; Daly MJ, Chakravarti A. A genome-wide linkage and association scan reveals novel loci for autism. Nature. 2009 Oct 8;461(7265):802-8. doi: 10.1038/nature08490. PMID: 19812673; PMCID: PMC2772655.
Prenatal Environment is Important
Hallmayer J, Cleveland S, Torres A, et al. Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism. Arch Gen Psychiatry. 2011;68(11):1095–1102. doi:10.1001/archgenpsychiatry.2011.76
Autism is More Than the
Sum of Its Parts.
Anderson, G.M. (2008). The potential role for emergence in autism. Autism Research, 1(1), 18–30. DOI: 10.1002/aur.2
The Path to Treatment is Through the Synapse
Geschwind D.H. & State M.W. (2015). Gene hunting in autism spectrum disorder: on the path to precision medicine. Lancet Neurology, 14(11), 1109–1120. DOI: 10.1016/S1474-4422(15)00044-7
From Genetics to Drug Development
Vorstman J.A.S. et al. (2014). Using genetic findings in autism for the development of new pharmaceutical compounds. Psychopharmacology, 231(6), 1063–1078. DOI: 10.1007/s00213-013-3334-z
Most Genetic Risk for Autism
Resides with Common Variation
Gaugler T. et al. (2014). Most genetic risk for autism resides with common variation. Nature Genetics, 46(8), 881–885. DOI: 10.1038/ng.3039